Toxicol Rev. 2004;23(3):145-57. The role of diazepam in the treatment of nerve agent poisoning in a civilian population. Marrs TC(1). Author information:.
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There is considerable experimental evidence to support the hypothesis that diazepam (and other anticonvulsants) may prevent structural damage to the central nervous system as evidenced by neuropathological changes such as neuronal necrosis at autopsy. These studies show that diazepam is an efficacious anticonvulsant in nerve agent poisoning. Diazepam should be given to patients poisoned with nerve agents whenever convulsions or muscle fasciculation are present. Numerous pharmacodynamic studies of the action of diazepam in animals experimentally poisoned with nerve agents have been undertaken. Diazepam is also useful as an anxiolytic in those exposed to nerve agents. Consequently, the use of diazepam is an important part of the treatment regimen of nerve agent poisoning, the aim being to prevent convulsions or reduce their duration. In instances of nerve agent poisoning during terrorist use in Japan, diazepam seems to have been an effective anticonvulsant. It is likely that convulsions may have long-term sequelae in the central nervous system, because of damage by anoxia and/or excitotoxicity. In severe poisoning, diazepam administration should be considered even before these complications occur. In nearly all of these, diazepam has been studied in combination with other antidotes, such as atropine and/or pyridinium oximes, sometimes in combination with pyridostigmine pretreatment. The main site of action of diazepam, as with other benzodiazepines, is at the GABA(A) receptor, although it has been suggested that some of the potentially beneficial actions of diazepam in nerve agent poisoning are mediated through other means.
Diazepam exhibits various effects on motor nerves and skeletal muscle: 1. The maximum conduction velocity is decreased, 2. the duration of.
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the latency between the electrical and the mechanical response is increased, 4. the duration of the negative component of the muscle action potential is increased, 3. The maximum conduction velocity is decreased, 2. the muscle contracts and 5. relaxes more slowly, and 6. the muscle force is reduced particularly with repetitive activation. Diazepam exhibits various effects on motor nerves and skeletal muscle: 1.
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Advertisement. der Erschlaffung des Muskels und 6. eine Reduktion der Muskelkraft auch für repetitive Kontraktionen. eine Verlangsamung der Kontraktionsgeschwindigkeit und 5. Diazepam bewirkt im Bereich des motorischen Erfolgsorgans 1. eine Verzögerung der maximalen Nervenleitgeschwindigkeit, 2. eine Verbreiterung der negativen Phase des Muskelaktionspotentials, 3. eine Verlängerung der elektromechanischen Latenz, 4.
Like many people my age (I'm 48), I've tried marijuana and Valium in the past. Today, I drink alcohol on a social basis, as well as beta blockers.
Like many people my age (I'm 48), I've tried marijuana and Valium in the past. Let's start with full disclosure. I am a professional musician - an oboist - and have performed with four major orchestras in the US, including the New York Philharmonic. Today, I drink alcohol on a social basis, as well as beta blockers, which are prescribed by my doctor, and which I take for performance anxiety once or twice a year.
Tranquilisers like Valium have similar consequences to alcohol: they compromise technique and response time.
New Evidence On Addiction To Medicines: Diazepam Has Effect On Nerve Cells In The Brain Reward System. Date: August 29, 2008; Source: Academy of.
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However, over time patients may develop an increased tolerance towards these medicines and an unhealthy dependence. Benzodiazepines are highly effective medicines that are widely used in the treatment of anxiety, insomnia, pains, panic attacks and other symptoms.
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Furthermore, neural message transmission in the dopamine cells is reinforced for up to 72 hours after ingestion of diazepam.
Masui. 2003 Dec;52(12):1286-92. [How do diazepam and flumazenil influence respiratory control by the activities of both hypoglossal and phrenic nerves in.
To estimate the influence of benzodiazepines on the respiratory control, we studied the effect of diazepam and flumazenil on the neural activity and the respiratory response caused by a brief (60 sec) respiratory arrest (RA) observed in the hypoglossal nerve (HG) and phrenic nerve (PH) in rabbits.