Vaginal diazepam has been used by patients who have pelvic pain as an the option to have the medication compounded into a cream or suppository, a side effect of drowsiness, otherwise no side effects were reported.
VAS scores decreased on average from 4.8 to 3.4, average vulvar Q-Tip level decreased from 3.3 to 1.2, and vulvar pain levels decreased at one month follow-up as well. Only 1/3 of the women reported a side effect of drowsiness, otherwise no side effects were reported.Interestingly, some patients found it helpful to insert the medication vaginally 1 hour prior to engaging in intercourse so that pain was reduced.
Of course, pelvic rehab practitioners are well-trained to address the muscles via direct releases as well as through the use of other modes, yet having assistance of pharmacology may be a useful tool for the patient.
She's prescribed me a starter dosage of Prozac to help me relax, and a vaginal suppository of diazepam to help my muscle spasming. she.
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Melissa. But once I see them, and I insert the first dilator for them, or I work with them, and encourage them to insert the dilator, they are much more successful at home. I will even see patients once a week to help them move up in dilator size. I have had many patients who have tried to do a dilation program on their own, but have been unsuccessful. Keep us updated.
I hope this is the proper place to post this.
Aimee has written: “I also find that adding vaginal valium along with dilation can make dilation a bit easier.”
I will share a couple of their posts (see below).
About this study. The purpose of this study is to gather information on the pharmacokinetics and side effects of vaginally administered diazepam.
Mayo Clinic principal investigator Isabel Green, M.D. Closed for enrollment Karen Ishitani R.N.
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Participant eligibility includes age, gender, type and stage of disease, and previous treatments or health concerns. If you need assistance understanding the eligibility criteria, please contact the study team. Guidelines differ from study to study, and identify who can or cannot participate. Inclusion Criteria : Exclusion Criteria:.
Describes the nature of a clinical study. Types include: Observational study — observes people and measures outcomes without affecting results. Study IDs Site IRB Rochester, Minnesota: Sponsor Protocol Number: About this study The purpose of this study is to gather information on the pharmacokinetics and side effects of vaginally administered diazepam. Medical records research — uses historical information collected from medical records of large groups of people to study how diseases progress and which treatments and surgeries work best. Interventional study (clinical trial) — studies new tests, treatments, drugs, surgical procedures or devices.
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Benzodiazepines (Valium, or diazepam, is a benzodiazepine) are typically not A new study confirms the lack of effect of vaginal Valium for pelvic floor muscle spasm and pain. The subjects used a 10 mg vaginal Valium suppository every night for 28 days or a At least I didn't have any adverse effects.
Notify me of new comments via. Dr. Jen Gunter.
Why does rectal gravol work then??? Or any rectal med??? Not disputing that the studies may have been lame but saying that vaginal route is topical may be incorrect. There are other studies that show it to have more absorption for other medications than oral. Vagina is mucosa like mouth and rectum. It is not topical skin.
Jen Gunter - April 8, 2014. Pingback: The speculum setting or shutting of comments on some posts to limit woo| Dr.
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This causes less drowsiness as a side effect than oral valium, but.. chart review of vaginal diazepam suppository use in high-tone pelvic floor.
1Department of Urology, San Matteo Hospital of Pavia, Pavia, Italy.
The method proposed for active determination in the tablets and ampoules was suitably adapted to vaginal formulations. According to this colorimetric method, diazepam yields intensely red colored product when it reacts with 3,5-dinitrobenzoic acid in alkaline medium. In order to evaluate diazepam loaded into pessaries, a spectrophotometric method was set up. The red complex is called Meisenheimer complex, and the reaction is called Janovsky reaction.
The promising results obtained in this study represent the opportunity to develop a clinical study, when it is possible to evaluate its therapeutic efficacy on the interstitial cystitis patients.
An alternative route to rectal administration of diazepam can be considered the intravaginal route, to consider adjunctive treatment of bladder pain in interstitial cystitis.